Dr. Mordechay SchlesingerDepartment of Physics, University of Windsor
Exploiting Tumour Pressure to Predict Response to Treatment
Co-Investigators and Collaborators:
*Dr. Schlesinger passed away suddenly in the Fall of 2015 within weeks of completing the tenure of his Seeds4Hope Research Grant. Consequently, the Year 2 Progress Report was prepared and submitted by his research team lead by one of the project Co-Investigators, Dr. Stephen Brown.
EVIDENCE OF PROGRESSThe Seeds-4-Hope (S4H) funding have allowed a group of otherwise unconnected University of Windsor physicists and clinical cancer practitioners at Metropolitan Hospital and the Windsor Regional Cancer Centre to work together to develop a new non-invasive tool that has the potential to determine a tumor’s aggressiveness and acute response to therapy. The funds from the S4H were used to support a postdoctoral fellow (PDF) in the Physics Department at the University of Windsor. The PDF effectively liaised between Windsor institutions. Under the supervision of the Principal Investigator, the PDF developed the mathematical process and translated the procedure using magnetic resonance (MR) images from human cancers.
Previously, other investigators have demonstrated that the pressure in a tumor is a diagnostic measure of the tumor’s aggressiveness (potential to grow, invade and metastasize). However, the procedure was invasive, requiring a large bore needle to be imbedded in the mass.
The investigators funded by the S4H demonstrated using contrast-enhanced MR images of human tumors, that the region of enhancement increased as a function of time after the injection on the contrast agent and furthermore, that the rate of increase in volume was dependent on the pressure gradient between the tumor and the surrounding normal tissue. By measuring the fluid velocity from MR images, the investigators assessed the tumor interstitial fluid pressure (TIFP), non-invasively.
The S4H project was a success because it lay the groundwork for the investigators to collect critically important preliminary data that will be used in future grant applications. The results of the S4H studies have been published in peer-reviewed scientific journals.
Unfortunately, the Principal Investigator of the project, Dr. Mordechay Schlesinger, passed away as the project reached its successful completion. The other investigators are committed to continuing to build on the success of the S4H project as Dr. Schlesinger would have wanted.